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Total CBD consumer sales U.S. 2014-2022 | Statista Thus, the CBD consumer market is following the trend of the total legal cannabis market in the United States, which is projected to be a 23-billion-dollar business by 2025. Cannabidiol - Wikipedia Cannabidiol may be an antagonist of GPR55, a G protein-coupled receptor and putative cannabinoid receptor that is expressed in the caudate nucleus and putamen in the brain. It also may act as an inverse agonist of GPR3, GPR6, and GPR12. CBD has been shown to act as a serotonin 5-HT 1A receptor partial agonist.
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